Chapter category: Cytokines/Growth Factors
IL-10 Gene Polymorphisms in Transplantation
Interleukin-10
Edited by: Francesco M. MarincolaISBN: 1-58706-285-2
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Chapter authors:
Andrey Morgun, Natalia Shulzhenko and Maria Gerbase-DeLima
Transplantation is currently the treatment of choice for end-stage insufficiency of various organs and severe hematologic disorders. Cytokine gene polymorphisms have been extensively explored in transplantation because they are thought to possibly explain the heterogeneity of courses and outcomes and to help in immunosuppression individualization. Although many polymorphisms have been described in the IL-10 gene, the -1082 single nucleotide polymorphism is the most investigated in transplantation. Furthermore, acute rejection is the endpoint most frequently used in cytokine gene polymorphisms studies in organ transplantation. It appears that factors such as effect of HLA and minor histocompatibility mismatch, type of donor, and type of immunosuppression are important to determine the influence of IL-10 gene polymorphisms on transplant outcome. Although there are several discrepancies between the results of studies of IL-10 gene polymorphisms and transplant outcome, it seems that recipient«s IL-10 polymorphisms may indicate the severity of acute graft versus host disease in bone marrow transplantation, frequency of acute rejection in organ transplantation and even could be associated with long-term renal graft outcome. In conclusion, data collected up to now demonstrate substantial evidence of IL-10 gene polymorphism involvement in post-transplant outcome. Multi-centric prospective studies using multi-locus approaches might ascertain when and how IL-10 genotype information should be considered in clinical transplant practice.
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