Chapter category: Gene Expression
Cellular Dedifferentiation During Regeneration: The Amphibian Muscle System
Reactivation of the Cell Cycle in Terminally Differentiated Cells
Edited by: Marco CrescenziISBN: 0-306-47423-9
» Get more information about this book at landesbioscience.com «
Chapter authors:
Elly Tanaka
[+] view image
Amphibian limb regeneration represents a striking system where the reversal of muscle cell differentiation occurs in response to physiological stimuli. During this process, dedifferentiation is used to form progenitor cells for tissue repair. In response to injury, multinucleated muscle cells resolve into mononucleate cells that undergo proliferation.
The extracellular signal that initiates S–phase re–entry from the differentiated state is a serum factor that is distinct from known polypeptide growth factors such as FGF or PDGF. The factor is activated by thrombin proteolysis thus closely linking the initiation of dedifferentiation to wound healing.
Additional chapters from this book:
Reversal of Terminally Differentiated State in Skeletal Myocytes by SV40 Large T Antigen
Takeshi Endo
Terminal differentiation of mammalian skeletal muscle cells had long been thought to result in irreversible arrest in G0 phase of the cell cycle. Such terminally differe...
Cellular Dedifferentiation During Regeneration: The Amphibian Muscle System
Elly Tanaka
Amphibian limb regeneration represents a striking system where the reversal of muscle cell differentiation occurs in response to physiological stimuli. During this process, dedi...
Cell Cycle Reactivation in Skeletal Muscle and Other Terminally Differentiated Cells
Alessandra Sacco, Deborah Pajalunga, Lucia Latella, Francesca Siepi, Alessandro Rufini and Marco Crescenzi
This Chapter reviews, in a historical perspective, our current understanding of the cell cycle control in terminally differentiated skeletal muscle cells. Attempts at inducing reen...
Regulation of Cardiomyocyte Proliferation and Apoptosis
Kishore B.S. Pasumarthi, Adil I. Daud and Loren J. Field
Myocardial function is compromised in several forms of heart disease due to the loss of cardiomyocytes and in part to the limited ability of surviving myocytes to re–enter the...
Myocyte Proliferation in Heart Failure
Jan Kajstura, Annarosa Leri, Antonio Beltrami, Carlo A. Beltrami, Edmund H. Sonnenblick and Piero Anversa
The results summarized in this short Chapter challenge the perennial dogma that cardiac myocytes are terminally differentiated cells. Unequivocal evidence of mitosis is provided...
