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Chapter category: Reproductive Biology
Important Role of Shh Controlling Gli3 Functions During the Dorsal-Ventral Patterning of the Telencephalon
Chapter authors:
Jun Motoyama and Kazushi Aoto
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The dorsal-ventral patterning of the telencephalon is a crucial for the normal brain
function, because it determines the proportion of two different types of basic neurons,
glutamatergic excitatory neurons and GABAergic inhibitory neurons. The secreted
protein sonic hedgehog (Shh) is required for the ventral cell specification, whereas zinc finger
transcription factor Gli3 seems to be important for the dorsal cell type specification. Recent
studies suggest that how both Gli3 and Shh control the normal proportion of dorsal and ventral
cell types to generate appropriate tissue size and shape during brain development. These
observations may offer a new aspect to our understanding of activity gradient of Shh signal
during brain development.
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