[x] close
Chapter category: Circadian Rhythms
Circadian Rhythms in Neurospora crassa: Beyond the frq Gene
Chapter authors:
Patricia L Lakin-Thomas
[+] view image
The frq/wc transcription/translation feedback loop is often assumed to be at the core of
the molecular mechanism generating circadian rhythmicity in Neurospora crassa. This
chapter reviews the evidence that the frq/wc feedback loop is insufficient to explain the
complexity of rhythmicity in Neurospora. Three issues are discussed: 1) the major role played
by post-transcriptional control of FRQ protein levels; 2) the existence of rhythmicity in the
absence of a functional frq/wc feedback loop; and 3) questions about the role of frq/wc in
controlling rhythmic conidiation. The circadian system may be a network of oscillators, and
the role of frq/wc may be thought of as an integrator of environmental signals.
» Access chapter for $19
