Chapter category: Immunology
Adding Complexity to Phagocytic Signaling: Phagocytosis-Associated Cell Responses and Phagocytic Efficiency
Molecular Mechanisms of Phagocytosis
Edited by: Carlos RosalesISBN: 0-387-25419-6
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Chapter authors:
Erick Garcia-García and Carlos Rosales
Regulation of the phagocytic process involves complex signaling pathways that lead to particle internalization and destruction. Phagocytosis, however, is not a cellular response occurring as an isolated event. Phagocytic signaling involves the regulation of many phagocytosis-associated cell responses that are important for host defense and for the resolution of the inflammatory process. In addition, due to the destructive nature of the phagocytic process, this cell response is tightly controlled, and phagocytes must respond to activation and differentiation signals that modulate their phagocytic efficiency. Presently it is unclear how all these events are coordinated. Available information, however, suggests a model in which phagocytosis-associated cell responses are regulated through signaling pathways that occur in parallel to, and partially overlap those regulating the ingestion process itself. Additionally, activation and differentiation signals appear to potentiate, or modify the utilization important signaling enzymes that regulate phagocytosis, in order to make this process more efficient.
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