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Chapter category: Heat Shock Proteins

The Role of Hsps in Neuronal Differentiation and Development

This chapter appears in the following book:

Heat Shock Proteins in Neural Cells

Edited by: Christiane Richter-Landsberg
ISBN: 0-387-39952-6
» Get more information about this book at landesbioscience.com «

Chapter authors:
Kate Reed Herbert, Afshin Samali and Adrienne Gorman*


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Heat shock proteins (Hsps) are expressed during development of the nervous system in a temporally and spatially controlled pattern that does not appear to be linked to activation of heat shock transcription factors. The distinct patterns of Hsp expression suggest that they perform unique roles during development and neuronal differentiation. Studies indicate that these proteins can inhibit programmed cell death, regulate cytoskeletal dynamics during neurite outgrowth and axon pathfinding, as well as interact with and regulate intracellular signaling molecules that are involved in neuronal differentiation. Overall, through their involvement in these various processes, expression of Hsps favours neuronal differentiation and survival and, as such, Hsps are emerging as important regulators of the delicate balance between cell death and survival/differentiation during development of the nervous system.

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Additional chapters from this book:

The Role of Heat Shock Proteins during Neurodegeneration in Alzheimer’s, Parkinson’s and Huntington’s Disease

Andreas Wyttenbach* and André Patrick Arrigo

A number of acute and chronic neurodegenerative conditions are associated by protein misfolding and aggregation of proteins within and outside cells. Misfolded proteins and protein aggregation are c...

Assembly of Protein Aggregates in Neurodegeneration: Mechanisms Linking the Ubiquitin/Proteasome Pathway and Chaperones

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In recent years, it has become increasingly evident that the majority of neurodegenerative disorders is associated with the aggregation and deposition of proteins in inclusion bodies. To avoid thi...

Heat Shock Proteins and the Regulation of Apoptosis

Una FitzGerald, Adrienne M. Gorman and Afshin Samali

Since the elucidation of their functions in protein folding and translocation, heat shock protein chaperones have been a target of research in all spheres of biomedicine. Within the last five years,...

The Role of Hsps in Neuronal Differentiation and Development

Kate Reed Herbert, Afshin Samali and Adrienne Gorman*

Heat shock proteins (Hsps) are expressed during development of the nervous system in a temporally and spatially controlled pattern that does not appear to be linked to activation of heat shock trans...

Heat Shock Proteins in Multiple Sclerosis

Celia F. Brosnan, Luca Battistini and Krzysztof Selmaj

In this review, we have addressed the possible contribution of heat shock proteins (HSP) to the pathogenesis of multiple sclerosis (MS), a chronic inflammatory demyelinating disease of the central ner...

Heme Oxygenase as a Therapeutic Funnel in Nutritional Redox Homeostasis and Cellular Stress Response: Role of Acetylcarnitine

Vittorio Calabrese, Giovanni Pennisi, Menotti Calvani, Annamaria Giuffrida, D. Allan Butterfield and Cesare Mancuso

Reduction of cellular expression and activity of antioxidant proteins and the consequent increase of oxidative stress are fundamental causes for both the aging processes and neurodegenerative diseases...

Heat Shock Proteins: Expression and Functional Roles in Nerve Cells and Glia

Christiane Richter-Landsberg

Heat shock proteins (HSPs) or so called stress proteins have multifunctional roles and are involved in many physiological processes, such as cell cycle control, cell proliferation, development, organi...

Small Heat Shock Proteins and the Cytoskeleton: Their Role in Inclusion Body Formation in Glial Cells

Christiane Richter-Landsberg and Olaf Goldbaum

The integrity of the cytoskeleton is an essential determinant for the function and survival of nerve cells and glia, and hence provides a sensitive target for stress situations. The small heat s...


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