Chapter category: DNA Surveillance and Repair
Oxidative Damage and Promoter Function
Oxidative Damage to Nucleic Acids
Edited by: Mark D. Evans and Marcus S. CookeISBN: 978-0-387-72973-2
» Get more information about this book at landesbioscience.com «
Chapter authors:
David Mitchell and Rita Ghosh
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David Mitchell
The University of Texas M.D. Anderson Cancer Center
Rita Ghosh
The University of Texas M.D. Anderson Cancer Center
Additional chapters from this book:
The Role of Antioxidants in the Prevention of Oxidative Damage to Nucleic Acids
Peter Møller and Steffen Loft
It is commonly assumed that ingestion of antioxidants is associated with low levels of oxidatively damaged DNA although this is far from conclusive in human intervention trials. A collective i...
OGG1: From Structural Analysis to the Knockout Mouse
Arne Klungland, Jon K. Laerdahl and Torbjørn Rognes
Among the four DNA bases, guanine, having the lowest redox potential, is the most susceptible to oxidation, and among the oxidized bases 7,8-dihydro-8-oxoguanine (8-oxoG) is certainly the lesion...
Oxidative Damage and Promoter Function
David Mitchell and Rita Ghosh
Evidence is accumulating that base damage, particularly that produced by oxidation reactions, can modulate DNA protein interactions and affect promoter function. Such lesions have the capacity t...
Oxidative DNA Damage and Telomere Shortening
Torsten Richter and Thomas von Zglinicki
Telomeres are highly complex DNA-protein structures that protect the ends of chromo- somes. A variety of DNA damage response and repair proteins are bound to telomeres and fulfil functions in the...
Prevention of the Mutagenecity and Cytotoxicity of Oxidized Purine Nucleotides
Yusaku Nakabeppu, Mehrdad Behmanesh, Hiroo Yamaguchi, Daisuke Yoshimura and Kunihiko Sakumi
Damage to nucleic acids is particularly hazardous because the genetic information in genomic DNA, such as nuclear and mitochondrial DNA, can be altered. Damage accumulated in cellular DNAs often...
Nucleic Acid Oxidation and the Pathogenesis of Cardiovascular Diseases
Maria Grazia Andreassi
Cardiovascular disease is the dominant health problem in the western world. The most frequent underlying cause of cardiovascular disease is atherosclerosis. The cellular and molecular mechanisms...
Oxidative DNA Damage and Carcinogenesis
Ryszard Olinski, Marek Foksinski and Barbara Tudek
In living cells, there is a steady formation of DNA lesions. A substantial number of these lesions are formed by endogenous factors such as reactive oxygen species (ROS) that damage DNA on a con...
Processing of 3´-End Modified DNA Strand Breaks Induced by Oxidative Damage
Jason L. Parsons, Emma Boswell and Grigory Dianov
In living cells, the DNA molecule is subject to attack from reactive oxygen species generated as the result of endogenous oxidative metabolism and exogenous factors, such as ionising radiation. ...
The Physiological and Pathological Roles of Oxidative Damage to DNA in Relation to Life-Stage
Alberto Izzotti
Oxidative damage to DNA (ODD) is a common phenomenon occurring during all life stages in all aerobic organisms. To evaluate the biological significance of ODD, we monitored 8-hydroxy-2'-deoxygua...
The Role of Oxidative Damage to Nucleic Acids in the Pathogenesis of Neurological Disease
V. Prakash Reddy, Ayse Beyaz, George Perry, Marcus S. Cooke, Lawrence M. Sayre and Mark A. Smith
Oxidative stress involving reactive oxygen species (ROS) and reactive nitrogen species (RNS) is integral to the process of aging and age-related diseases such as Alzheimer disease (AD), Parkinso...
Chlorination and Nitration of DNA and Nucleic Acid Components
Clare L. Hawkins, David I. Pattison, Matthew Whiteman and Michael J. Davies
Activated phagocytes generate a complex mixture of oxidants that are believed to be crucial to bacterial cell killing. However, excessive or misplaced generation of these oxidants is known to da...
Analysis of 8-Hydroxy-2´-Deoxyguanosine as a Marker of Oxidatively Damaged DNA in Relation to Carcinogenesis and Aging
H. Kasai, T. Hirano, K. Kawai, Y. Tsurudome, H. Itoh, D. Himeji and T. Horiuchi
Reactive oxygen species (ROS) are well known hazards for living organisms and are believed to be associated with the induction of cancer. ROS induce many forms of oxidative damage to proteins, n...
Oxidative Damage and Repair in the Mitochondrial Genome
Lene Juel Rasmussen and Keshav K. Singh
DNA is constantly exposed to damaging agents from both endogenous and exogenous sources. If this damage is not repaired, it can lead to mutations and result in cellular dysfunction, including un...
Oxidatively Damaged DNA and Inflammation
Peter Dedon and Marita C. Barth
Chronic inflammation has long been associated with diseases such as cancer and cardiovascular disease, with infectious processes playing a causal role in many types of cancer. One potential link...
Oxidatively Generated Damage to Cellular DNA: Mechanistic Aspects
Jean Cadet, Thierry Douki, Carine Badouard, Alain Favier and Jean-Luc Ravanat
In this chapter emphasis is placed on recent aspects of the oxidative formation of several classes of modified bases in cellular DNA that arise from the reaction of the hydroxyl radical (•OH), s...
Nucleotide Incision Repair: An Alternative and Ubiquitous Pathway to Handle Oxidative DNA Damage
Sophie Couvé-Privat, Alexander A. Ishchenko, Jacques Laval and Murat Saparbaev
Aerobic respiration and exogenous factors such as ionizing radiation and drugs generate reactive oxygen species (ROS). DNA has limited chemical stability and it is one of the most biologically i...
