Chapter category: Endocrine
b Cell Proliferation as the Major Determinant of Pancreatic b Cell Mass
Islet Cell Growth Factors
Edited by: Rohit N. KulkarniISBN: TBA
» Get more information about this book at landesbioscience.com «
Chapter authors:
Zvi Granot and Yuval Dor
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Additional chapters from this book:
Role of Parathyroid Hormone-Related Protein and Lactogens in the Pancreatic Beta Cell
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With the current rate of escalation in diabetes worldwide the need to treat and cure the disease is imperative from the standpoint of avoiding both a health and a related economic crisis in the ...
Role of FoxO Proteins in Pancreatic b Cells
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Forkhead transcription factors of the FoxO family have important roles in cellular proliferation, apoptosis, differentiation and stress resistance. FoxO proteins also play important roles in m...
b Cell Proliferation as the Major Determinant of Pancreatic b Cell Mass
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A fundamental problem in pancreas biology concerns the cellular origins of adult pancreatic b cells. Identifying the cells that give rise to new b cells will have important implications for th...
Hepatocyte Growth Factor (HGF) and the Pancreatic Beta Cell
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Studies performed in vivo using genetically modified mouse models have shown that growth factors are regulators of beta cell growth and differentiation. Hepatocyte growth factor (HGF), initially...
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The serine-threonine kinase Akt also known as protein kinase B is one of the most studied molecules. In addition to the important role in carcinogenesis, Akt is a major regulator of carbohydrate metab...
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Cells regulate proliferation by entering and progressing through the cell cycle. Conversely, cell growth is arrested by exiting the cell cycle. A balance of extrinsic and intrinsic signals nor...
Role of Pdx-1 in β-Cell Growth
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PDX-1 is a homeodomain transcription factor that acts as a key regulator of pancreas development, pancreatic b-cell differentiation, and b-cell function. It is one of the earliest markers of pancreati...
