Chapter category: Adhesion Molecules
Somatostatin Receptors: Distribution in Normal Tissues and Transduction Mechanisms
Somatostatin Analogs in Diagnostics and Therapy
Edited by: Marek PawlikowskiISBN: 978-1-58706-223-0
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Chapter authors:
Gabriela Melen-Mucha and Slawomir Mucha
receptors belonging to the family of G protein coupled receptors. So far five SST receptor subtypes (sst1-5) have been cloned and characterized. The genes for these receptor subtypes are localized on different chromosomes and are intronless, with one exception concerning sst2, which exists in two forms (sst2A, sst2B). Native SST existing mainly in two molecular forms (14 or 28 amino acid peptide) binds to all five sst subtypes with high nanomolar affinity, however some minor differences exist. The commercially available SST analogs (octreotide and lanreotide) bind only with high affinity to sst2 and sst5. Based on the binding studies with different SST analogs the family of SST receptors was divided into two subclasses. Subtype 1 and 4 of sst create one subclass and react poorly with these analogs, whereas sst2,3 and sst5 bind these analogs with high affinity comparable to that of native SST.
Additional chapters from this book:
Somatostatin Analogs—New Perspectives
Gabriela Melen-Mucha and Marek Pawlikowski
Acromegaly and so-called neuroendocrine tumors (carcinoids, pancreatic endocrine tumors) are at present the only routine indications for somatostatin (SST) analogs therapy. However, the progre...
The Treatment of Acromegaly with Somatostatin Analogs
Nuria Sucunza, Mª José Barahona and Susan M. Webb
Although transsphenoidal surgery of pituitary micro or macroadenomas is the treatment of choice in most acromegalic patients, somatostatin analogs are the first choice for medical treatment, eit...
Somatostatin Receptors: Distribution in Normal Tissues and Transduction Mechanisms
Gabriela Melen-Mucha and Slawomir Mucha
receptors belonging to the family of G protein coupled receptors. So far five SST receptor subtypes (sst1-5) have been cloned and characterized. The genes for these receptor subtypes are localized...
Somatostatin Receptors in Human Tumors: In Vitro Studies
Marek Pawlikowski
Neoplastic cells express and often even over-express the somatostatin receptors. It is important because the presence of sst receptors predicts—to some extent—the possibility of treatment with...
Physiology of Somatostatin
Marek Pawlikowski
Somatostatin (SST) was originally discovered as a hypothalamic peptide which inhibits growth hormone (GH) secretion from the pituitary gland. It appears in two molecular forms, composed from 14 ...
The Treatment of Neuroendocrine Tumors (NET) with Somatostatin Analogs
Beata Kos-Kudla
There is increasing interest in somatostatin (SST) analogs in the diagnosis and therapy of neuroendocrine tumors (NET), which constitute a heterogeneous group of neoplasms often associated with ...
Somatostatin Analogs: Lessons in Functional Complexity and Receptor Interactions
Michael D. Culler
Somatostatin (SST) was originally isolated from the hypothalamus as the key suppressor GH secretion, but is now known to be widely distributed throughout the body and to be involved in numerous ...
Radiolabeled Somatostatin Analogs in the Diagnosis and Therapy of Neuroendocrine Tumors
Leszek Królicki, Jolanta Kunikowska and Marianna I. Bak
The proof of the principle, that many tumors are characterized by a high expression of somatostatin receptors, has provided the background for the use of somatostatin analogs in the diagnostic process...
