Chapter category: Adhesion Molecules
Somatostatin Receptors in Human Tumors: In Vitro Studies
Somatostatin Analogs in Diagnostics and Therapy
Edited by: Marek PawlikowskiISBN: 978-1-58706-223-0
» Get more information about this book at landesbioscience.com «
Chapter authors:
Marek Pawlikowski
Neoplastic cells express and often even over-express the somatostatin receptors. It is important because the presence of sst receptors predicts—to some extent—the possibility of treatment with SST analogs. The presence of sst receptors may be examined in vivo, by means of the receptor scintigraphy using the radiolabeled SST analogs. The receptors can be also detected in vitro (ex vivo) on surgical or biopsy specimens. Among the in vitro (ex vivo) methods, the immunohistochemical investigation with specific anti-receptor antibodies seems to be particularly useful for routine diagnostics. The chapter discusses the data on the incidence of sst1-5 receptor subtypes in the different human tumors including pituitary adenomas, brain tumors, thyroid and adrenal tumors, neuroendocrine tumors (NET), and nonendocrine cancers. These data lead to the conclusion that the expression of sst receptors is not restricted to the neuroendocrine and endocrine tumors but can be detected also in nonendocrine malignancies. The above suggests that the latter are also candidates to the therapeutic trials with SST analogs. On the other hand, this possibility is limited by the fact that the detectable sst receptors are not always functional.
Additional chapters from this book:
Somatostatin Analogs—New Perspectives
Gabriela Melen-Mucha and Marek Pawlikowski
Acromegaly and so-called neuroendocrine tumors (carcinoids, pancreatic endocrine tumors) are at present the only routine indications for somatostatin (SST) analogs therapy. However, the progre...
The Treatment of Acromegaly with Somatostatin Analogs
Nuria Sucunza, Mª José Barahona and Susan M. Webb
Although transsphenoidal surgery of pituitary micro or macroadenomas is the treatment of choice in most acromegalic patients, somatostatin analogs are the first choice for medical treatment, eit...
Somatostatin Receptors: Distribution in Normal Tissues and Transduction Mechanisms
Gabriela Melen-Mucha and Slawomir Mucha
receptors belonging to the family of G protein coupled receptors. So far five SST receptor subtypes (sst1-5) have been cloned and characterized. The genes for these receptor subtypes are localized...
Somatostatin Receptors in Human Tumors: In Vitro Studies
Marek Pawlikowski
Neoplastic cells express and often even over-express the somatostatin receptors. It is important because the presence of sst receptors predicts—to some extent—the possibility of treatment with...
Physiology of Somatostatin
Marek Pawlikowski
Somatostatin (SST) was originally discovered as a hypothalamic peptide which inhibits growth hormone (GH) secretion from the pituitary gland. It appears in two molecular forms, composed from 14 ...
The Treatment of Neuroendocrine Tumors (NET) with Somatostatin Analogs
Beata Kos-Kudla
There is increasing interest in somatostatin (SST) analogs in the diagnosis and therapy of neuroendocrine tumors (NET), which constitute a heterogeneous group of neoplasms often associated with ...
Somatostatin Analogs: Lessons in Functional Complexity and Receptor Interactions
Michael D. Culler
Somatostatin (SST) was originally isolated from the hypothalamus as the key suppressor GH secretion, but is now known to be widely distributed throughout the body and to be involved in numerous ...
Radiolabeled Somatostatin Analogs in the Diagnosis and Therapy of Neuroendocrine Tumors
Leszek Królicki, Jolanta Kunikowska and Marianna I. Bak
The proof of the principle, that many tumors are characterized by a high expression of somatostatin receptors, has provided the background for the use of somatostatin analogs in the diagnostic process...
