Chapter category: Signal Transduction
Centriole Inheritance
Protein-Based Inheritance
Edited by: Yury O. ChernoffISBN: 978-1-58706-138-7
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Chapter authors:
Patricia G. Wilson
Early cell biologists perceived centrosomes to be permanent cellular structures. Centrosomes were observed to reproduce once each cycle and to orchestrate assembly of a transient mitotic apparatus that segregated chromosomes and a centrosome to each daughter at the completion of cell division. The molecular picture of centrosomes is now more complete. Centrosomes are composed of a pair of centrioles buried in a complex pericentriolar matrix. The bulk of microtubules in cells lie with one end buried in the pericentriolar matrix and the other extending outward into the cytoplasm. Centrioles recruit and organize pericentriolar material. As a result, centrioles dominate microtubule organization and spindle assembly in cells born with centrosomes. Centriole inheritance is ensured by cell cycle checkpoints that monitor the presence of centrosomes in G1 and spindle bipolarity in mitosis. In spite of these cell cycle controls, assembly of bipolar spindles in acentriolar cell extracts and cell proliferation in acentriolar mutants argue that neither centrioles nor centrosomes are essential structures. This review examines the recent advances in understanding centriole inheritance.
Patricia G. Wilson
Regenerative Bioscience Center, Department of Animal and Dairy Science, University of Georgia
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