Chapter category: Endocrine
How Might PTHs Stimulate Bone Growth?
Growing Bone
Second Edition
Edited by: James F. WhitfieldISBN: 978-1-58706-156-1
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Chapter authors:
James F. Whitfield
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James F. Whitfield
Institute for Biological Sciences
National Research Council of Canada
Ottawa, Ontario, Canada
Additional chapters from this book:
Strontium, Calcium’s Big Brother
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Strontium (Sr) has been very recently hyped as the latest “paradigm-changing” thing in the treatmen of osteoporosis as indicated by the title of a paper by Reginster et al (2003)—“Strontium Ranelate: ...
Surface Signaling Steroids—Real Anabolics or Pseudo-Anabolics?
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In 1998 Sicinski et al reported the synthesis of new 1a, 25-(OH)2-19-nor-vitamin D3 analogs such as 2MD (2-methylene-19-nor-(20S)-1a,25(OH)2D3) which are super-potent derivatives of the natural 1a, 25...
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While the PTHs are by far the leading anabolic agents for treating osteoporosis and mending fractures, another family of drugs has been trying to challenge them but with very mixed results (Mundy, 200...
OGP—The Osteogenic Growth Peptide
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Scooping out the marrow or driving a nail into the marrow cavity of a bone such as the tibia, like a fracture, causes the marrow cavity to fill with a blood clot and releases a shower of osteogenic si...
The Clinical Prospects of the Invincible PTHs
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The osteoporosis market is a rapidly growing “marketer’s” dream. And several years ago there was no known bone-growing drug—only the ever-worrisome (for cancerophobics) estrogens and the other antires...
How Might PTHs Stimulate Bone Growth?
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To tackle the formidable job of understanding how the PTHs stimulate bone growth in humans, rodents and other animals (Fig. 17) we must know where and how things start. What signals do they send into...
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So far it has seemed that estrogen is the primus inter pares of an ever-growing number of agents that control bone growth and strength in both women and, perhaps surprisingly, men (Baylink et al, 1999...
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At first sight bones are inert, rock-like things that store 99% of the body’s calcium and consist of a hard shell, the cortex, that encloses a deceptively delicate lattice of struts and plates (Jee, 2...
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Osteoporotic postmenopausal women don’t need to fall or hit something to break their fragile bones. Their, hips, ribs, wrists and especially vertebrae are apt to be broken or crushed by bending spines...
