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Chapter category: Transplant

Cellular and Molecular Biology in Organ Ischemia‑Reperfusion Injury

This chapter appears in the following book:

Organ Preservation for Transplantation,
Third Edition

Edited by: Luis H. Toledo-Pereyra
ISBN: TBA
» Get more information about this book at landesbioscience.com «

Chapter authors:
Shohachi Suzuki


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Ischemia‑reperfusion injury (IRI) is a multifactorial disorder which leads to cellular damage and organ dysfunction. A vast number of studies on IRI have shown that this critical pathophysiological condition is a result of inflammatory response with polymorphonuclear neutrophil‑endothelial interaction characterized by the activation of complement system, the production of reactive oxygen species, cytokines, chemokines and the other mediators and the synthesis of adhesion molecules through signal transduction pathways. This chapter is a comprehensive review on the current status of the cellular and molecular mechanisms in organ IRI and potential strategies to protect tissue from functional and structural damages caused by IRI. Better understanding of basic pathophysiology on organ IRI will show how to avoid risk factors that may aggravate IRI and will result in the manifestation of potential targets in therapeutic interventions for this insult.

Shohachi Suzuki
Second Department of Surgery, Hamamatsu University School of Medicine

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Additional chapters from this book:

Cellular and Molecular Biology in Organ Ischemia‑Reperfusion Injury

Shohachi Suzuki

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The removal of an organ, which is subjected to an unnatural environment necessitates special management strategies that differ from in vivo management. The normal human body and the bodies of other ma...


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