Chapter category:

Introduction to Ion Channels

This chapter appears in the following book:

Integrins and Ion Channels:
Molecular Complexes and Signaling

Edited by: Andrea Becchetti and Annarosa Arcangeli
ISBN: TBA
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Chapter authors:
Chiara Di Resta and Andrea Becchetti

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Ion channels are integral membrane proteins that contain pathways through which ions can flow. By shifting between closed and open conformational states (‘gating’ process), they control passive ion flow through the plasma membrane. Channels can be gated by membrane potential, or specific ligands, or other agents, such as mechanical stimuli. The efficacy of the gating process and the kinetics of subsequent inactivation or desensitization are regulated by intracellular mechanisms. Many types of membrane channels exist, with different degrees of ion selectivity. By controlling ion fluxes, they typically regulate membrane potential and excitability, shape the action potential, trigger muscle contraction and exocytosis (through Ca2+ influx), regulate cell volume and many other cellular processes. In the first part of the chapter, we give a brief introduction to the main physiological aspects of ion channels, which may not be familiar to molecular biologists. Subsequently, as a reference for later chapters, we summarize the main structural and functional features of the channel‑proteins presently known to be related to integrin receptors.

Chiara Di Resta

Andrea Becchetti
Universita di Milano-Bicocca

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Additional chapters from this book:

Introduction to Ion Channels

Chiara Di Resta and Andrea Becchetti

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Chapter category:

Introduction to Ion Channels

Integrins and Ion Channels: Molecular Complexes and Signaling

Additional chapters from this book:

Introduction to Ion Channels

Integrin Receptors and Ligand-Gated Channels

Coordinated Regulation of Vascular Ca2+ and K+ Channels by Integrin Signaling

Adhesion‑Dependent Modulation of Macrophage K+ Channels

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Integrins and Ion Channels:
Molecular Complexes and Signaling