Chapter category: Angiogenesis
PECAM-1 and Angiogenesis
Angiogenesis Inhibitors and Stimulators: Potential Therapeutic Implications
Edited by: Shaker A. MousaISBN: 1-58706-022-1
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Chapter authors:
Horace M. DeLisser
Angiogenesis, the formation of new vessels from a preexisting vasculature depends critically on the ability of the capillary endothelial cells to sever their normal cellcell associations, to migrate through extracellular matrix, and to reform their cellcell attachments to generate new capillaries. In the initial stages, adhesive interactions between endothelial cells and the extracellular matrix are dominant thus facilitating endothelial cell invasion of and migration through the extravascular matrix. Later, adhesive interactions between endothelial cells are supreme thereby promoting the organization of vascular tubes. The adhesive interactions of endothelial cells with each other and with the extracellular matrix, along with the adhesion receptors that mediate these interactions, are thus of fundamental importance to this process.1,2 This indicates important roles for endothelial cellcell adhesion molecules and endothelial cellmatrix adhesion molecules (e.g., integrins) in the formation of new vessels. The participation avb3 and avb5 integrins in in vivo angiogenesis has been demonstrated and progress has made in understanding their role in vessel formation (discussed in Chapter 3). Recently, evidence has emerged to implicate another endothelial cellcell adhesion molecule, PECAM1, in angiogenesis.3 In this chapter we will review the data that has established a role for PECAM1 in in vivo angiogenesis as well as the emerging data which suggests that it may be involved at several of the stages of the formation of new vessels.
Additional chapters from this book:
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Regulation of Angiogenesis by Fibroblast Growth Factors
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Polypeptide factors which directly influence the migratory and proliferative activity of the human endothelial cell in vitro are well recognized as mediators of human angiogenesis in vivo. It ...
The Role of Vascular Endothelial Growth Factor in Angiogenesis
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Thrombospondin and Angiogenesis
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Thrombospondin1 (TSP1) is an extracellular matrix molecule that is produced by numerous cell types, including endothelial cells, fibroblasts, macrophages, monocytes, keratinocytes, ...
PECAM-1 and Angiogenesis
Horace M. DeLisser
Angiogenesis, the formation of new vessels from a preexisting vasculature depends critically on the ability of the capillary endothelial cells to sever their normal cellcell associations, to m...
Integrin av in Health and Disease—Role of avb3 in Metastasis, Vascular Remodeling and Angiogenesis
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The invasion, migration, proliferation and survival of cells are now known to be regulated in part by members of the integrin family of cell adhesion proteins. The integrin family is composed ...
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The formation of new capillary blood vessels, a process termed "angiogenesis", is dependent upon coordinate production of angiogenesis promoters and suppressors. Angiogenesis is ...
