Chapter category: MHC
Skin-Specific Minor Histocompatibility Antigens: A Critical Appraisal
Minor Histocompatibility Antigens: From the Laboratory to the Clinic
Edited by: Derry C. RoopenianISBN: 1-57059-599-2
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Chapter authors:
David Steinmuller
In 1962 Silverman and Chin1 reported that some radiation chimeras they had constructed rejected skin grafts from the bone marrow cell (BMC) donor without losing BM chimerism. The model was a xenogeneic one, lethally irradiated C57BL mice restored with Sprague-Dawley rat BMC, and the authors were not the first to report that chimeras do not always accept donor strain skin grafts; in 1959 Billingham and Brent2 had reported that strain A mice given (C57BL x CBA)F1 hybrid spleen cells (SC) at birth became stable BM chimeras that accepted CBA but not C57BL skin grafts, a phenomenon they referred to as "split tolerance." However Silverman and Chin were the first to propose an explanation for the effect based on skin-specific histocompatibility (H) antigens. If the hematopoietic system of the BM chimera developed in the absence of donor skin, the chimeras should not be tolerant to donor skin-specific alloantigens; donor skin grafts therefore would be viewed as foreign and rejected. Based on "the long time required for completion of the rejection" (an average of 20-61 days in different experiments) Silverman and Chin likened the skin-specific reactions they observed to reactions against minor H antigens like H3 and HY.1
Additional chapters from this book:
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Skin-Specific Minor Histocompatibility Antigens: A Critical Appraisal
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Minor histocompatibility (H) antigens are readily studied in the HLA identical Bone Marrow Transplantation (BMT) setting. BMT in combination with chemoradiotherapy is used as a treatment for s...
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Minor H antigens have two fundamental characteristics:
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HY was not the first minor histocompatibility (H) antigen to be detected in mice, since the work of several investigators during the first half of the 20th century had previously establishe...
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Histoincompatibility was first detected in mice at the beginning of the 20th century. The great majority of the loci responsible for this complex genetic trait are located on the autosomal chr...
