Chapter category: Heat Shock Proteins
Hsp70 and Ischemia Tolerance in the Compromised Heart Ger J. van der Vusse
Heat Shock Proteins in Myocardial Protection
Edited by: Rakesh C. KukrejaISBN: 1-58706-021-3
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Chapter authors:
Luc H.E.H. Snoeckx, Richard N.M. Cornelussen, Robert S. Reneman and
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The discovery in eukaryotic and prokaryotic organisms of a prompt and specific response to heat shock, known as the heat shock response, has stimulated the development of a complete new research domain, in which the potential protective role of stress induced proteins in organisms, tissues, individual cells and subcellular structures under life threatening circumstances became the subject of intense investigations. During the last decade our knowledge of the action of stress proteins in organs such as the heart has grown impressively.
The potential of the expression of inducible stress proteins in hearts of experimental animals has been investigated in a variety of studies. In different mammalian animal species like rat and rabbit, using different models of ischemia, the tolerance of the heart against an ischemic insult was found to be improved by the activation of a powerful endogenous protective mechanism, based upon the enhanced expression of inducible and constitutive (cognate) stress proteins.1,2 In isolated hearts of young and adult animals, using various ischemia protocols, the expression of stress proteins as induced by whole-body heat stress 24 hours earlier, has been shown to improve postischemic functional recovery and to reduce infarct size following global or regional ischemia, respectively (for review see refs. 3 and 4). The beneficial role of these proteins was studied in even more detail in isolated cell cultures, in which individual stress proteins such as the major inducible stress protein of the 70 kDa family, i.e., Hsp70, were expressed after (viral) transfection.5-8 Experiments on hearts of transgenic animals with a constitutive overexpression of Hsp70 and experiments in which the expression of this protein was blocked by anti-sense oligonucleotides have shown that this protein plays a key role in the protection of the organ against the deleterious effects of ischemia and reperfusion.9-13
Additional chapters from this book:
Ischemia/Reperfusion Injury and Heat Shock Proteins
Junichiro Nishizawa and Kazuhiro Nagata
Ischemic heart disease or myocardial infarction remains the most prevalent cause of death in developed countries despite advances in modern medicine. Recent advances in diagnosis and treatment...
Physiological Role of Heat Shock Protein 27
Dipak K. Das and Nilanjana Maulik
Heat shock protein 27 (Hsp27) is a stress–inducible cytosolic protein that is ubiquitously present in many normal cells. The synthesis of Hsp27 is induced by heat shock and other envir...
Stress Proteins in Myocardial Protection: Culture Shock Protein, Heme Oxygenase–1 (Hsp32), Induced by Sublethal Stresses Protects the Heart Against Oxidative Stress
Shiro Hoshida
The formation of a stress protein comprises a mechanism of cell protection highly conserved in evolution. As the induction of stress proteins makes cells more tolerant towards a second, mor...
Antisense, Heat Shock Proteins and the Heart
A. A. Knowlton
Antisense technology provides a tool with which to dissect the components of the stress response. There are two known endogenous sets of protective proteins, the heat shock proteins (Hsps) and...
Preconditioning of Cardiac Myocytes: Studies Using Cultured Neonatal
Jan A. Post, Chris T.W.M. Schneijdenberg and Arie J. Verkleij
The acquisition of tolerance towards myocardial ischemia and reperfusion can be acquired by several preconditioning procedures. The original preconditioning protocol described for myocardia...
Hsp72 in the Regulation of TNF–a Production:
Xianzhong Meng
Myocardial ischemia/reperfusion induces the production of the cardiac depressant cytokine tumor necrosis factor–a (TNF–a). Macrophages (M
Hsp70 and Ischemia Tolerance in the Compromised Heart Ger J. van der Vusse
Luc H.E.H. Snoeckx, Richard N.M. Cornelussen, Robert S. Reneman and
The discovery in eukaryotic and prokaryotic organisms of a prompt and specific response to heat shock, known as the heat shock response, has stimulated the development of a complete new res...
Role of Heat Shock Proteins, Protein Kinase C and ATP-Sensitive Potassium Channel in Delayed Myocardial Protection
Rakesh C. Kukreja, Yong-Zhen Qian and Jeffery B. Hoag
Heat shock proteins (Hsp's) are one of the highly conserved proteins in existence, found in every organism.1 These proteins are synthesized quickly and intensely in response to stre...
Cardioprotection by Stress Proteins
Heat Shock Proteins in Myocardial Protection, edited by Rakesh C. Kukreja
Myocardial ischemia causes a series of changes at the intracellular level within the cardiomyocyte. These intracellular changes include changes in calcium levels, altered osmotic control, memb...
Heat Stress Proteins: A Possible Route to Myocardial Protection
Mohamed Amrani, Caroline C. Gray and Magdi H. Yacoub
Heat stress proteins (hsp) are induced by a variety of stimuli including elevated temperature,1 ischemia,2 hypoxia,3 pressure overload4 and some ...
Stress Proteins in Myocardial Protection
Richard Carroll and Derek M. Yellon
In all organisms examined heat stress results in the synthesis of a specific group of proteins known as the heat shock or stress proteins (Hsps). Cells that accumulate these proteins adapt ...
