Chapter category: Heat Shock Proteins

Hsp72 in the Regulation of TNF–a Production:

This chapter appears in the following book:

Heat Shock Proteins in Myocardial Protection

Edited by: Rakesh C. Kukreja
ISBN: 1-58706-021-3
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Chapter authors:
Xianzhong Meng

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Myocardial ischemia/reperfusion induces the production of the cardiac depressant cytokine tumor necrosis factor–a (TNF–a). Macrophages (Mf) are the main sources of tissue TNF–a, and nuclear factor–kB (NF–kB) is a key transcription factor regulating TNF–a production. Thus, NF–kB may represent a therapeutic target for myocardial dysfunction associated with dysregulated TNF–a production. Accumulating evidence shows that some known cardioprotective agents, such as adenosine, inhibit myocardial TNF–a production and that inhibition of NF–kB improves myocardial recovery after ischemia/reperfusion. Heat shock protein (Hsp) 72, an inducible isoform of 70 kD Hsp family, is expressed in the myocardium in response to various forms of stress and has been linked to myocardial functional resistance to ischemia/reperfusion. The mechanism by which cardiac Hsp72 preserves myocardial function during stress remains obscure. In vitro heat stress inhibits TNF–a production by monocytes or Mf following endotoxin stimulation. We have noted that cardiac interstitial cells including Mf preferentially express Hsp72 after whole body hyperthermia in rats and that this pattern of Hsp72 expression is associated with enhanced cardiac resistance to both subsequent endotoxemic and ischemic dysfunction. It is likely that Hsp72 plays an important role in the regulation of local inflammatory response and thereby preserves tissue function. Indeed, induction of Hsp72 downregulates stress–induced TNF–a production in tissues including the myocardium and lungs, and the downregulation of TNF–a production in the lungs has been attributed to inhibition of NF–kB. Further delineation of the role of cardiac Hsp72 in the regulation of myocardial NF–kB activity and TNF–a production, and the exploration of molecular interaction of Hsp72 with NF–kB will provide insights into the mechanism by which Hsp72 preserves myocardial function.

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Chapter category: Heat Shock Proteins

Hsp72 in the Regulation of TNF–a Production:

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