Chapter category: Cell Cycle
CDK-Activation in Fission Yeast Schizosaccharomyces pombe: Specificity Mediated
The CDK-Activating Kinase (CAK)
Edited by: Philipp KaldisISBN: 0-306-47438-7
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Chapter authors:
Thomas Westerling, Damien Hermand and Tomi P. Mäkelä
Activation of cyclin dependent kinases (CDKs) by phosphorylation of the conserved Tloop is a regulatory step of cell cycle progression that was discovered just a decade ago. A wealth of data regarding this activation and of potential CDK activating kinases (CAKs) has accumulated. Despite this several crucial unresolved issues remain, including the unambiguous identification of the in vivo CAK kinase(s) in mammalian species. Here we focus on recent advances in this field in fission yeast Schizosaccharomyces pombe and discuss the implications of these results in a broader context.
Additional chapters from this book:
Structural Aspects of CDK Activation
Nick R. Brown and Jane A. Endicott
Sequential activation of members of the cyclin-dependent kinase (CDK) family orders the events required for DNA replication and cell division. Both the CDK and cyclin families ha...
Activation of CDKs by CAK: CAK in TFIIH
Anne Keriel and Jean-Marc Egly
TFIIH was originally identified as a basal transcription factor involved in protein-coding genes transcription.1,2 The systematic cloning of its nine subunits r...
CDK-Activation in Fission Yeast Schizosaccharomyces pombe: Specificity Mediated
Thomas Westerling, Damien Hermand and Tomi P. Mäkelä
Activation of cyclin dependent kinases (CDKs) by phosphorylation of the conserved Tloop is a regulatory step of cell cycle progression that was discovered just a decade ago. A we...
Activating Phosphorylation of Cyclin-Dependent Kinases in Budding Yeast
Philipp Kaldis, Vasiliki Tsakraklides, Karen E. Ross, Edward Winter
The eukaryotic cell division cycle is controlled via the sequential activation and inactivation of cyclin-dependent protein kinases (cdks). In the budding yeast Sacchar...
CDK-Activating Kinases in Higher Plants
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Recent development in plant molecular genetics has facilitated our understanding of how plants accomplish their body plans in response to various environmental signals. Plants h...
Drosophila CDK7: A Paradigm for CAK in Metazoans
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Activation of cyclin dependent kinases (CDKs) by phosphorylation of the conserved Tloop is a regulatory step of cell cycle progression that was discovered just a decade ago. A wealth o...
The Evolution of CDK-Activating Kinases
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Cyclin-dependent kinases (CDKs) are essential regulators of the cell cycle and transcription. In the budding yeast Saccharomyces cerevisiae and the fission ...
CAK from Marine Invertebrates to Human
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The eukaryotic cell cycle is driven by an evolutionarily conserved engine consisting of a series of cyclin-dependent kinase (CDK)-cyclin modules. The orderly events of the cell cyc...
