Bioscience Chapter Database :: 3635 Chapters Now Online

Chapter category: Drug Design

Towards Activated Release of Payloads from Carrier Erythrocytes

This chapter appears in the following book:

Erythrocyte Engineering for Drug Delivery and Targeting

Edited by: Mauro Magnani
ISBN: 0-306-47691-6
» Get more information about this book at landesbioscience.com «

Chapter authors:
A.M. Rollan and A.P. McHale

Although the potential of erythrocytes as drug delivery vehicles has been suggested for some time, the applicability of this approach has been limited by the lack of a mechanism to achieve active release of payloads from the system. The scope of this chapter will be to review developments, potential applications and challenges associated with activated release of therapeutic agents from erythrocytes using external stimuli.

» Access chapter for $19



Additional chapters from this book:

Engineered Red Blood Cells as Circulating Bioreactors

P. Ninfali and E. Biagiotti

Over the last twenty years, enzymes encapsulated in red blood cells (RBC) have proven to be efficient bioreactors in the clearance of undesired molecules from the blood stream and have s...

Design and Synthesis of New Pro-Drugs to be Used with Carrier Red Blood Cells

S. ScarfÏ, G. Damonte and U. Benatti

Nowadays, increasing attention is devoted to new systems of controlled in vivo delivery of biologically active molecules, the primary aim being to overcome some disadvantages of conventional s...

Drug-Loaded Red Blood Cells for the Control of the Inflammatory Response: Selective Targeting of Nuclear Factor-kB (NF-kB)

R. Crinelli, A. Antonelli, M. Bianchi, L. Gentilini and M. Magnani

While the causes of inflammatory diseases remain unknown, transcription factors are increasingly being found to play a pivotal role in the development and maintenance of these pathologies. In ...

Erythrocytes as Carriers of Anthracycline Antibiotics in vitro and in

Victor M. Vitvitsky

Modern pharmacology largely relies on the use of drugs that selectively affect their target cells and tissues. The selectivity of antibacterial drugs of new generations is quite high. It comes...

Red Blood Cells as Carriers of Antiviral Agents

A. Fraternale, A. Casabianca and M. Magnani

In an attempt to overcome the problems of nucleoside analogue toxicity and of their limited efficacy and short plasma half-life we have investigated the possibility of using erythrocytes both ...

Engineered Nanoerythrocytes as a Novel Drug Delivery System

Sanjay Jain and N. K. Jain

Engineered nanoerythrocytes (nEs) as a novel controlled drug delivery system is a topic of interest to the pharmacist working in industry, research and development, academia, drug control admi...

Vaccination Strategy Using Red Blood Cells as Antigen Delivery System

Laura Chiarantini

The use of adjuvants is usually required to induce strong immunological responses to protein antigen. However, serious side effects preclude their use in human vaccines. Currently, the only ad...

Streptavidin-Mediated Coupling of Therapeutic Proteins to Carrier Erythrocytes

Vladimir R. Muzykantov and Juan-Carlos Murciano

Red blood cells (RBC) can provide a natural, safe and abundant carrier to prolong the life-time in the bloodstream and thus enhance the efficacy of certain therapeutic agents, while restrictin...

Targeting Drug Loaded Red Blood Cells

Mauro Magnani, Luigia Rossi and Giorgio Brandi

Targeting of drugs can be achieved in a number of ways usually conjugating the drug of interest with specific ligands or by engineering the properties of the carrier system. In this paper we s...

Towards Activated Release of Payloads from Carrier Erythrocytes

A.M. Rollan and A.P. McHale

Although the potential of erythrocytes as drug delivery vehicles has been suggested for some time, the applicability of this approach has been limited by the lack of a mechanism to achieve act...

Red Blood Cell Loading

Luigia Rossi, Sonja Serafini and Mauro Magnani

In this Chapter a selection of procedures for the encapsulation of a wide range of molecules into red blood cells is reported. Electroporation, drug-induced endocytosis, osmotic pulsing and hy...


SIGN IN

Email:


Password:


lost password?




[ Home | Authors | Editors | Custom Books | Chapter Reprints | Subscribe | Contact | Biotoons ]