Chapter category: Coagulation
Disease Specific Mechanisms of Disseminated Intravascular Coagulation
Molecular Mechanisms of Disseminated Intravascular Coagulation
Edited by: Hugo ten CateISBN: 1-58706-058-2
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Chapter authors:
J.A. Kremer Hovinga, J.M.M. Otten, M.M. Levi and Hugo ten Cate
Disseminated intravascular coagulation (DIC) is defined as an acquired syndrome characterized by widespread activation of coagulation leading to intravascular formation of fibrin and thrombotic occlusion of small and midsize vessels thereby compromising blood supply to various organs. Hitherto, it has not yet been clarified whether the activation of coagulation is triggered locally (i.e., KasabachMerritt syndrome) or in the entire vascular bed. It is also conceivable, that the coagulation process is initiated locally extending to the whole microcirculation or that coagulation activation takes place in the entire vascular system while the formation of thrombi is a local process.
J.A. Kremer Hovinga
J.M.M. Otten
M.M. Levi
Hugo ten Cate
Additional chapters from this book:
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Disease Specific Mechanisms of Disseminated Intravascular Coagulation
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Disseminated intravascular coagulation (DIC) is defined as an acquired syndrome characterized by widespread activation of coagulation leading to intravascular formation of fibrin and thrombotic occlus...
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Minor amounts of biologically active tissue factor (TF) are always constitutively present in circulating blood of healthy individuals. In various diseases, including those underlying the induction ...
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Thrombomodulin (TM) plays a role in regulation of the coagulation system not only by decreasing the procoagulant activities of thrombin, but by activation of protein C (PC) to form activated protein C...
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Disseminated intravascular coagulation (DIC) is a common clinical syndrome with dichotomous presentations of hemorrhage and thrombosis with a common underlying pathophysiology. As a syndrome, DIC pres...
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Contributions of the Plasma Kallikrein/Kinin System to Disseminated Intravascular Coagulation
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The Pleiotropic Effects of Tissue Factor
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