Ischemia-Reperfusion
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page 1 of 2 pages | next »Development of Manganese(II)-Based Superoxide Dismutase Mimics
Daniela Salvemini, Dennis P. Riley, Salvatore Cuzzocrea
The list of patho-physiological conditions associated with the over-production of super oxide anion expands every day. The most exciting realization is that there appears to be a commonality to the tissue injury observed in various disease states; and that superoxide anion, produces tissue injury...
Development of Manganese(II)-Based Superoxide Dismutase Mimics
Daniela Salvemini, Salvatore Cuzzocrea and Dennis P. Riley
The list of patho-physiological conditions associated with the over-production of super oxide anion expands every day. The most exciting realization is that there appears to be a commonality to the tissue injury observed in various disease states; and that superoxide anion, produces tissue injury...
Development of Manganic Porphyrin Mimetics of Superoxide Dismutase Activity
James D. Crapo, Brian J. Day and Irwin Fridovich
The generation of superoxide is an unavoidable consequence of aerobic metabolism and all aerobes require methods to detoxify it for survival. The superoxide dismutase (SOD) enzymes are the most common way aerobes detoxify superoxide. In humans, a number of pathologies involve the overproduction o...
Development of Manganic Porphyrin Mimetics of Superoxide Dismutase Activity
James D. Crapo, Brian J. Day and Irwin Fridovich
The generation of superoxide is an unavoidable consequence of aerobic metabolism and all aerobes require methods to detoxify it for survival. The superoxide dismutase (SOD) enzymes are the most common way aerobes detoxify superoxide. In humans, a number of pathologies involve the overproductio...
Evaluation of a Superoxide Dismutase Mimetic as an Adjunct to Interleukin 2 Based Cancer Therapy
Wolfram E. Samlowski, Ryan Petersen, John R. McGregor, Muralidher Kondapaneni and Daniela Salvemini
Interleukin-2 (IL-2) is currently used to treat patients with metastatic renal cell carcinoma and malignant melanoma. Clinical use of IL-2 is limited by severe side effects, particularly hypotension. Because of such dose-limiting side effects, the full period of IL-2 dosing is frequently curta...
Evaluation of a Superoxide Dismutase Mimetic As an Adjunct to Interleukin 2 Based Cancer Therapy
Wolfram E. Samlowski, Ryan Petersen, John R. McGregor, Muralidher Kondapaneni and Daniela Salvemini
Interleukin-2 (IL-2) is currently used to treat patients with metastatic renal cell carcinoma and malignant melanoma. Clinical use of IL-2 is limited by severe side effects, particularly hypotension. Because of such dose-limiting side effects, the full period of IL-2 dosing is frequently curtaile...
Interactions of Superoxide, Nitric Oxide and Superoxide Dismutase in Gastrointestinal Damage by Nonsteroidal Anti-inflammatory Drugs and Other Agents
Brendan J. R. Whittle and Dominique Lamarque
Mucosal injury to the gastrointestinal tract by nonsteroidal anti-inflammatory drugs (NSAIDs) is brought about by complex and multiple mechanisms that can involve the local production and actions of reactive oxygen species. Local infusion of superoxide generating mixtures, as well as high loca...
Interactions of Superoxide, Nitric Oxide and Superoxide Dismutase in Gastrointestinal Damage by Nonsteroidal Anti-inflammatory Drugs and Other Agents
Brendan J. R. Whittle and Dominique Lamarque
Mucosal injury to the gastrointestinal tract by nonsteroidal anti-inflammatory drugs (NSAIDs) is brought about by complex and multiple mechanisms that can involve the local production and actions of reactive oxygen species. Local infusion of superoxide generating mixtures, as well as high local d...
Oxidative Stress and Testicular Dysfunction
Jeffrey J. Lysiak, Terry T. Turner
This chapter will largely focus on reactive oxygen species (ROS) in certain testicular pathologies. The involvement of ROS in the cytotoxicity of spermatozoa has been known for decades; however, recent studies have also linked ROS to various pathologies of the testis including, cryptorchidism, ur...
Oxidative Stress and Testicular Dysfunction
Jeffrey J. Lysiak and Terry T. Turner
This chapter will largely focus on reactive oxygen species (ROS) in certain testicular pathologies. The involvement of ROS in the cytotoxicity of spermatozoa has been known for decades; however, recent studies have also linked ROS to various pathologies of the testis including, cryptorchidism,...
Role of Superoxide in Post-Ischemic Liver Injury
Ian N. Hines, Hirohisa Harada, Jason M. Hoffman, Kevin P. Pavlick, Sulaiman Bharwani, Robert Wolf and Matthew B. Grisham
Interruption of blood flow to the liver is an unavoidable consequence of liver transplantation and resectional surgery. A growing body of experimental evidence suggests that reperfusion of the ischemic liver initiates hepatocellular injury and inflammation culminating in severe liver injury an...
Role of Superoxide in Post-Ischemic Liver Injury
Ian N. Hines, Hirohisa Harada, Jason M. Hoffman, Kevin P. Pavlick, Sulaiman Bharwani, Robert Wolf and Matthew B. Grisham
Interruption of blood flow to the liver is an unavoidable consequence of liver transplantation and resectional surgery. A growing body of experimental evidence suggests that reperfusion of the ischemic liver initiates hepatocellular injury and inflammation culminating in severe liver injury and o...
Superoxide and Acquired Hearing Loss
Sandra L. McFadden, Dalian Ding, Edward Lobarinas and Richard J. Salvi
Age-related hearing loss (AHL), noise-induced hearing loss (NIHL), and drug-induced hearing loss (DIHL, or ototoxicity) are the three major types of acquired hearing loss in the adult population. Evidence suggests that cellular damage by reactive oxygen species (ROS) such as the superoxide free r...
Superoxide and Acquired Hearing Loss
Sandra L. McFadden, Dalian Ding, Edward Lobarinas and Richard J. Salvi
Age-related hearing loss (AHL), noise-induced hearing loss (NIHL), and drug-induced hearing loss (DIHL, or ototoxicity) are the three major types of acquired hearing loss in the adult population. Evidence suggests that cellular damage by reactive oxygen species (ROS) such as the superoxide fre...
Superoxide Dismutase and COPD
Rubin M. Tuder and Sonia Flores
The incidence of lung disease caused by chronic cigarette smoking is increasing dramati cally worldwide. One of the major clinical complications related to cigarette smoke is the destruction of lung tissue, thus resulting in emphysema. There is strong evidence that oxidative stress caused by th...
Superoxide Dismutase and COPD
Rubin M. Tuder and Sonia Flores
The incidence of lung disease caused by chronic cigarette smoking is increasing dramati cally worldwide. One of the major clinical complications related to cigarette smoke is the destruction of lung tissue, thus resulting in emphysema. There is strong evidence that oxidative stress caused by the ...
Superoxide Dismutase Deficiency in Asthma
Mercedes Arroliga, Serpil C. Erzurum and Suzy A.A. Comhair
Asthma is considered the most common chronic respiratory condition with a mortality increase of 31% in the last 7 years. Recent evidence implicates oxygen-derived free radicals as important mediators of inflammation in asthma. Although, the human lung has an effective, well-integrated antioxidant...
Superoxide Dismutase Deficiency in Asthma
Mercedes Arroliga, Serpil C. Erzurum and Suzy A.A. Comhair
Asthma is considered the most common chronic respiratory condition with a mortality increase of 31% in the last 7 years. Recent evidence implicates oxygen-derived free radicals as important mediators of inflammation in asthma. Although, the human lung has an effective, well-integrated antioxid...
Superoxide Dismutase Mimetics and Acute Renal Failure
Prabal Kumar Chatterjee and Christoph Thiemermann
Acute renal failure (ARF) affects as many as 5% of all hospitalised patients and has a high rate of mortality. To date, clinical treatment of patients suffering from ARF is still largely supportive and dialysis remains the only viable therapy. Therefore, the development of novel interventions ...
Superoxide Dismutase Mimetics and Acute Renal Failure
Prabal Kumar Chatterjee and Christoph Thiemermann
Acute renal failure (ARF) affects as many as 5% of all hospitalised patients and has a high rate of mortality. To date, clinical treatment of patients suffering from ARF is still largely supportive and dialysis remains the only viable therapy. Therefore, the development of novel interventions wit...
Superoxide Dismutase Mimetics: A New Approch to Cancer Therapy
Valentina Fabbroni, Simone Pierpaoli, Annamaria Di Felice and Emanuela Masini
The incidence of cancer is increasing because of aging of the population, reduction in the mortality of competing serious illness, and better diagnostic methods. In the developed world, roughly one in three people contract cancer and around one in four of those die from the disease. The worldw...
Superoxide Dismutase Regulating Apoptosis in Cancer Development: Therapeutic Implications
José M. Matés and Maite Asenjo
Metabolism of oxygen, and the resulting toxic by-products can causes cancer and death. The oxygen paradox tells us that oxygen is both necessary for aerobic life and toxic to all life forms. Free radical in form of active oxygen, named superoxide, now touch every biological and medical discipl...
The Role of Superoxide in Acute and Chronic Inflammation
Salvatore Cuzzocrea and Daniela Salvemini
Avast number of experimental and clinical studies implicates oxygen-derived free radicals (especially, superoxide and hydroxyl radical) and high energy oxidants (such as peroxynitrite) as mediators of acute and chronic inflammation. Superoxide anion can modulate a wide range of toxic oxidative...
The Role of Superoxide in Acute and Chronic Inflammation
Salvatore Cuzzocrea, Daniela Salvemini
A vast number of experimental and clinical studies implicates oxygen-derived free radi cals (especially, superoxide and hydroxyl radical) and high energy oxidants (such as peroxynitrite) as mediators of acute and chronic inflammation. Superoxide anion can modulate a wide range of toxic oxidative ...
The Role of Superoxide in Heart Disease
James J. Galvez and R. Mark Payne
Is a common event in human pathophysiology. Ischemia occurs when blood flow has slowed, or stopped, and cannot meet the metabolic demands of the tissues. This happens, for example, in the event of stroke or heart attack. It also happens in the more predictable settings of surgery, such as coronar...
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